Ovulation induction with LH-RH in rats rendered acyclic by hypophysial grafts

Induction of ovulation in hens by an analogue of LH-RH.

Ovulation and Endocrine Response after Lh-rh in Domestic Animals

cows 2 weeks after parturition and in diestrous and proestrous heifers. Serum LH concentrations increased after LH-RH treatment and the greatest response was observed in cows with ovarian follicular cysts. Serum progesterone concentrations were increased at 6 hours after LH-RH in animals which had functional luteal tissue in the ovaries but serum estradiol and estrone were unchanged. Ovarian fo...

Down-regulation of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) in rats by LH-RH antagonist Cetrorelix.

Antagonists of luteinizing hormone-releasing hormone (LH-RH), unlike the LH-RH agonists, suppress gonadotropins and sex steroid secretion immediately after administration, without initial stimulatory effects. [Ac-D-Nal(2)1,D-Ph(4Cl)2,D-Pal(3)3,D-Cit6,D-Ala10]LH-R H (SB-75; Cetrorelix) is a modern, potent antagonistic analog of LH-RH. In this study, the binding characteristics of receptors for L...

Suppression of serum LH-RH and LH in rats by an inhibitor of norepinephrine synthesis.

Monoamine synthesis inhibitors have been used extensively to unravel the role of neurotransmitters in the hypothalamic regulation of pituitary LH release (Coppola, Leonardi & Lippmann, 1966; Kordon & Glowinski, 1972; Kalra, P.S. & McCann, 1973). Inhibition of tyrosine hydroxylase by \g=a\-methyl-paratyrosine(Corrodi & Hansen, 1966) or dopamine-\g=b\-hydroxylaseby sodium diethyldithiocarbamate (...

Further investigation of the antiovulatory effects of the antiprogestational steroid RMI 12,936 in the rat.

Inhibition of ovulation by RMI 12,936 was associated with suppression of the pro-oestrous peak of hypothalamic dopamine. The antiovulatory effect was not reversed by administration of oestrogen, was partly reversed by progesterone and was fully reversed by oestrogen and progesterone. Hypophysial sensitivity to LH-RH, known to be reduced by RMI 12,936, remained low when ovulation was restored by...